|Egg Donor Services
Egg donation is a very cost effective way of completing your family when your major problem is poor egg quality. This is especially true for older women; women with poor ovarian reserve; and those who have failed multiple IVF cycles because of a poor ovarian response or poor embryo quality.
While it's hard for some women to accept the fact that using donor eggs means your child will not have a direct genetic tie with you, many women are very happy with this option because:
- It has a very high success rate. Our success rates are better than 56% per cycle when we do donor egg IVF.
- You experience pregnancy and childbirth and can bond better with your baby.
- It's your name on your child's birth certificate.
- No social pressures are involved in this option, as the donation is anonymous and confidential.
- It's much less expensive and much more cost effective than surrogacy.
So what's the process ?
You first need to send me your medical details by filling in the form at www.drmalpani.com/malpaniform.htm
I only need the results of the following simple medical tests before starting a donor egg IVF cycle.
- Semen analysis for your husband (to check his sperm count and motility).
- Blood tests for you for the following reproductive hormones - PRL ( prolactin) and TSH (thyroid stimulating hormone) . Do this from a reliable lab like SRL ( www.srl.in)
- A vaginal ultrasound scan on Day 10 or 11 which should check for the following:
- ovarian volume
- antral follicle count
- uterus morphology
- endometrial thickness and texture
Please send me the detailed test results and medical reports . You can scan them in as a single Word file and email them to me. If the tests have been done in the past one year, there is no need to repeat them. If there is a problem, then we can treat it prior to starting IVF!
Once we have confirmed that donor egg IVF is your best option, you then need to decide when you want to start your treatment.
You need to send an advance of US $ 1000 ( approx Rs. 50,000 ) so we can reserve your egg donor for you.
You can do this by wire transfer.
Receiving banks full address:
Citibank, 293 Dr D. N. Road, Fort, Mumbai
MALPANI INFERTILITY CLINIC PVT.LTD.
CITI BANK N.A. FORT BRANCH ,293,D.N.RD.MUMBAI 400001.
CURRENT A/C NO- 0451062115
IFSC CODE-- CITI 0100000
BANK MICR NO-- 000037000.
It takes us 1-3 months to reserve your donor and to synchronise your cycles. If you send me your photo and physical details, I will match a donor for you and send you her non-identifying traits.
How much does all this cost ?
Our charges for a donor egg IVF treatment cycle are US $ 6500.
This includes all medical treatments and procedures. Payment to the donor would cost about US $ 1000 more. Second cycles are often much less expensive, because we can freeze supernumerary embryos and then transfer these.
Caucasian and black egg donors now available !
We have partnered with egg donor agencies in Ukraine and South Africa which means we can now help you arrange for black and caucasian egg donors as well. However, the cost for these egg donors would be US $ 5000 more.
Treatment takes only 20 days
Donor egg IVF treatment starts from Day 1 ( the day the bleeding starts) of your cycle. At this time, we downregulate you by starting you on Inj Lupride ( GnRH analog mfr by Sun Pharma) , 0.2 ml sc daily . On Day 3, we do an ultrasound scan to confirm there is no ovarian cyst, after which we start your treatment with 4 tablets daily of Progynova ( estradiol valerate, 2 mg each).
We do the next scan on Day 10, after which you would have to be in Bombay for about 10 days. Your husband is needed on Day 14-Day 16 ( the day of the egg pickup). All the treatment is performed at our clinic, which means you never have to go elsewhere.
This is what the daily schedule would look like:
Day 1: Inj Lupride, 0.2 ml sc. ( Downregulation starts)
Day 2: Inj Lupride, 0.2 ml sc.
Day 3: Inj Lupride, 0.2 ml sc. Vaginal ultrasound scan to confirm there is no ovarian cyst. If there is no cyst, we can commence treatment.
Day 4: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 5: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 6: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 7: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 8: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 9: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Day 10: Inj Lupride, 0.2 ml sc. Tab Progynova ( 2 mg) 4 tab daily
Vaginal ultrasound scan to monitor endometrial thickness. The Lupride injection and Progynova will continue on a daily basis, until the donor's follicles are mature. This is usually Day 14- Day 16 for most patients. At this time, an HCG injection will be given, and the donor's eggs retrieved 36 hours after this. Your husband will need to provide a sperm sample at this time. Embryo transfer is performed 2 days later; and supernumerary embryos , if any, are cryopreserved. After the transfer, luteal phase support is provided with daily Progynova ( estradiol valerate2 mg, 3 tab daily; and Uterogestan ( 200 mg), 3 vaginal suppositories daily.
You can travel back 3 days after the embryo transfer. 14 days after the transfer, you need to do a blood test for beta HCG to confirm a pregnancy.
Our book, Getting Pregnant - A Guide for the Infertile Couple, which is online at www.DrMalpani.com has more details on the treatment and our clinic.
You can print out a sample calendar of your treatment cycle at http://www.ivfindia.com/ivfcalendar3.php. If your local doctor is willing to help, you can start your treatment locally, and fly down directly on Day 10. This way you'll only have to stay 10 days in India !
Frozen ( vitrified) eggs
We are now also pleased to be able to offer frozen eggs for our donor egg IVF program ! A major limitation of donor egg IVF in the past was that we were able to use only fresh eggs. This meant that we had to synchronise your cycle with that of the donor - a process which could take 2-3 months. Now, with frozen eggs, we do not need to do so, which means we can do a donor egg IVF cycle whenever you are ready ! The only disadvantage is that you are not likely to have supernumerary embryos to freeze when you use frozen donor eggs. However, the advantage is that you do not need to wait - and the success rates are as good with fresh eggs.
IVF labs have been routinely freezing sperm and embryos for many years. However, freezing eggs has always been a challenge. This is because the egg is the largest cell in the body and contains a large quantity of water. Using conventional slow freezing techniques meant that this intracellular water would often form ice crystals while the egg was frozen, resulting in the egg being damaged.
However, using a new technique called vitrification ( vitros = glass) or flash freezing, we can now reliably freeze eggs as well.
How does vitrification work ? The principle is simple. This new method of cryopreservation allows ultra-rapid freezing. We put the eggs in very small droplets of vitrification solution in special straws, and plunge them directly in liquid nitrogen. This means the egg is cooled from 37 C to -196 C in a few seconds , so that the water does not get a chance to crystallize ! Vitrification uses a very high concentration of antifreeze solution (DMSO and ethylene glycol), allowing instant super-cooling into solid with no ice crystal formation at all.
Of course, it is not quite as simple as it might sound. Such high concentrations of antifreeze could be toxic to cells. This is why technical skill, experience and expertise is critically important ! Using this vitrification technique for freezing, we can reliably preserve eggs as well as embryos so that the pregnancy rate is as good as with fresh eggs.
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